Cardiac transplantation after heparin-induced thrombocytopenia: A systematic review.

Authors

• Diana C Jimenez
• Eric D Warner
• Danial Ahmad
• Jake L Rosen
• Nawar Al-Rawas
• Rohinton J Morris
• Rene Alvarez
• J Eduardo Rame
• John W Entwistle
• H Todd Massey
• Vakhtang Tchantchaleishvili

Publication/Presentation Date

2-1-2022

Abstract

PURPOSE: Heparin-induced thrombocytopenia (HIT) presents a unique challenge in patients requiring orthotopic heart transplantation (OHT). We sought to pool the existing evidence in a systematic review.

METHODS: Electronic search was performed to identify all relevant studies on OHT in patients with HIT. Patient-level data for 33 patients from 21 studies were extracted for statistical analysis.

RESULTS: Median patient age was 51 [IQR 41, 55] years, with 75.8% (25/33) males. All patients had a clinical diagnosis of HIT, and anti-PF4/Heparin antibodies were positive in 87.9% (29/33). Median lowest reported platelet count was 46 × 10

CONCLUSION: Heparin use during OHT may be associated with less adverse effects compared to use of other anticoagulants with no difference in 30-day mortality.

Volume

36

Issue

2

First Page

14567

Last Page

14567

ISSN

1399-0012

Published In/Presented At

Jimenez, D. C., Warner, E. D., Ahmad, D., Rosen, J. L., Al-Rawas, N., Morris, R. J., Alvarez, R., Rame, J. E., Entwistle, J. W., Massey, H. T., & Tchantchaleishvili, V. (2022). Cardiac transplantation after heparin-induced thrombocytopenia: A systematic review. Clinical transplantation, 36(2), e14567. https://doi.org/10.1111/ctr.14567

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

34927287

Department(s)

Administration and Leadership

Document Type

Article