Comparative Outcomes of Surgical and Transcatheter Aortic Valve Replacement: A Meta-Analysis and Parametric Extrapolation of Clinical Trials.
Publication/Presentation Date
10-1-2024
Abstract
INTRODUCTION: We aimed to pool randomized clinical trials (RCTs) comparing surgical aortic valve replacement (SAVR) with transcatheter aortic valve replacement (TAVR) and extrapolate pooled time-to-event data to compare long-term outcomes.
METHODS: An electronic database search was performed for RCTs comparing SAVR with TAVR. The most current longest follow-up data for each RCT were included. Data were pooled using a random-effects model. Survival data were pooled for Kaplan-Meier analysis as well as parametric modeling with extrapolation.
RESULTS: Seven RCTs comprising 7774 patients were included. Mean valve gradient at 5 y was comparable between SAVR [11 mmHg (3.7; 18.3)] and TAVR [8.1 mmHg (1.9; 14.3)] (P = 0.38). TAVR had a higher mean valve area at 30 d, 1 y, and 2 y [1.68 cm
CONCLUSIONS: Pooled all-cause mortality as well as pooled composite of all-cause mortality or stroke indicated better survival with SAVR at 5 y. Long-term parametric extrapolation also indicated superior survival with SAVR.
Volume
302
First Page
1
Last Page
11
ISSN
1095-8673
Published In/Presented At
Ahmad, D., Dawes, A., Im, M., Vishnevsky, A., Ruggiero, N. J., Plestis, K. A., Massey, H. T., Morris, R. J., Entwistle, J. W., & Tchantchaleishvili, V. (2024). Comparative Outcomes of Surgical and Transcatheter Aortic Valve Replacement: A Meta-Analysis and Parametric Extrapolation of Clinical Trials. The Journal of surgical research, 302, 1–11. https://doi.org/10.1016/j.jss.2024.06.044
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
39067157
Department(s)
Administration and Leadership
Document Type
Article