Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.
Publication/Presentation Date
1-1-1993
Abstract
Rat C6 glioma cells express insulin-like growth factor I (IGF-I) and form rapidly growing tumors in syngeneic animals. When transfected with an episome-based vector encoding antisense IGF-I complementary DNA, these cells lost tumorigenicity. Subcutaneous injection of IGF-I antisense-transfected C6 cells into rats prevented formation of both subcutaneous tumors and brain tumors induced by nontransfected C6 cells. The antisense-transfected cells also caused regression of established brain glioblastomas when injected at a point distal to the tumor. These antitumor effects result from a glioma-specific immune response involving CD8+ lymphocytes. Antisense blocking of IGF-I expression may reverse a phenotype that allows C6 glioma cells to evade the immune system.
Volume
259
Issue
5091
First Page
94
Last Page
97
ISSN
0036-8075
Published In/Presented At
Trojan, J., Johnson, T. R., Rudin, S. D., Ilan, J., Tykocinski, M. L., & Ilan, J. (1993). Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science (New York, N.Y.), 259(5091), 94–97. https://doi.org/10.1126/science.8418502
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8418502
Department(s)
Administration and Leadership
Document Type
Article