Platelet immunoregulatory factors.
Publication/Presentation Date
1-1-1996
Abstract
A number of soluble and membrane-associated proteins are known to mediate platelet:leukocyte interactions. Platelet-derived factors that have attracted the most attention to date include transforming growth factor beta, interleukin 1 and platelet factor 4. Recently, we have uncovered another protein within platelets that has leukocyte modulatory activity. It was previously characterized as an endometrial glycoprotein named placental protein 14 (PP14) with suppressive effects upon lymphocyte proliferation, pro-inflammatory cytokine production and natural killer cell function. The "hematopoietic" PP14 derived from cells of the megakaryocytic lineage shares this immunosuppressive property, as evaluated by two-way mixed lymphocyte cultures. Interestingly, two alternatively spliced hematopoietic PP14 mRNAs have been cloned which differ in their encoded proteins. Cell-free translation and transfection analyses have verified the translatability of both PP14 mRNA species and allowed for the analysis of their glycosylation properties. PP14, a member of the lipocalin structural superfamily of proteins, now offers an intriguing new link between the coagulation and immune systems.
Volume
14 Suppl 1
First Page
240
Last Page
245
ISSN
1066-5099
Published In/Presented At
Tykocinski, M. L., Xiong, N., & Morrow, D. M. (1996). Platelet immunoregulatory factors. Stem cells (Dayton, Ohio), 14 Suppl 1, 240–245. https://doi.org/10.1002/stem.5530140731
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11012227
Department(s)
Administration and Leadership
Document Type
Article