CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells.
Publication/Presentation Date
9-15-1990
Abstract
Antisense and sense transfection technologies were employed in cellular coculture systems to investigate the physiologic requirements for CD8-dependent immunoregulation. Our data indicate that cells bearing genetically engineered CD8 molecules incorporating a glycoinositolphospholipid membrane anchor, as well as fixed cells bearing natural CD8 molecules, retain specific, CD8-dependent immunoregulatory activity. These findings together support the novel concept that CD8, a molecule traditionally thought of as a receptor, can function as an inhibitory ligand. CD8-dependent inhibition was shown to induce nonresponsiveness, persisting for at least 24 h, in Ag-specific responders. Moreover, only cells undergoing primary, but not secondary, antigenic stimulation through their TCR were found to be susceptible to CD8-dependent inhibition. Both CD4+ and CD8+ responding T cells were inhibited by CD8+ modulatory cells. These functional analyses of inhibitory and responder cells in CD8-dependent inhibition lay the groundwork for developing artificial CD8-based immunomodulatory peptides and deciphering CD8's role in natural immunoregulation.
Volume
145
Issue
6
First Page
1646
Last Page
1652
ISSN
0022-1767
Published In/Presented At
Hambor, J. E., Kaplan, D. R., & Tykocinski, M. L. (1990). CD8 functions as an inhibitory ligand in mediating the immunoregulatory activity of CD8+ cells. Journal of immunology (Baltimore, Md. : 1950), 145(6), 1646–1652.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1697305
Department(s)
Administration and Leadership
Document Type
Article