A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds.
Publication/Presentation Date
12-15-2001
Abstract
The activation of discrete T-cell responses depends on the triggering of individualized threshold numbers of T-cell receptors (TCRs). The results of this study indicate that the lipocalin placental protein 14 (PP14), a T-cell inhibitor produced by cells of the reproductive and hematopoietic systems, mediates its anti-inflammatory activity by elevating the T-cell activation threshold, thereby rendering T cells less sensitive to stimulation. Significantly, the data demonstrate hierarchical sensitivity of selected cytokine responses to PP14-mediated inhibition, with the hierarchy reflecting their respective activation thresholds. These findings suggest a novel paradigm for immunoinhibition wherein negative regulators can finely tune, rather than inactivate, T-cell responses, and thereby skew the cytokine output of immunologic responses.
Volume
98
Issue
13
First Page
3727
Last Page
3732
ISSN
0006-4971
Published In/Presented At
Rachmilewitz, J., Riely, G. J., Huang, J. H., Chen, A., & Tykocinski, M. L. (2001). A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds. Blood, 98(13), 3727–3732. https://doi.org/10.1182/blood.v98.13.3727
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11739178
Department(s)
Administration and Leadership
Document Type
Article