Differential regulation of Th1/Th2 cytokine responses by placental protein 14.
Publication/Presentation Date
11-1-2004
Abstract
The potency of TCR signaling during primary CD4+ T cell activation influences initial cytokine expression patterns and subsequent polarization toward either Th1 or Th2 subsets. In this study, we demonstrate that the T cell inhibitor placental protein 14 (PP14; glycodelin) preferentially inhibits Th1 cytokine responses and chemokine expression when present during ex vivo priming of CD4+ T cells. PP14 synergizes with exogenously added IL-4 in skewing T cell responses. Significantly, PP14 impairs the down-regulation of GATA-3 transcriptional regulator expression that normally accompanies T cell activation, which is a prerequisite for Th1 development. Taken together, these data document for the first time the ability of PP14 to skew Th responses.
Volume
173
Issue
9
First Page
5524
Last Page
5530
ISSN
0022-1767
Published In/Presented At
Mishan-Eisenberg, G., Borovsky, Z., Weber, M. C., Gazit, R., Tykocinski, M. L., & Rachmilewitz, J. (2004). Differential regulation of Th1/Th2 cytokine responses by placental protein 14. Journal of immunology (Baltimore, Md. : 1950), 173(9), 5524–5530. https://doi.org/10.4049/jimmunol.173.9.5524
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15494501
Department(s)
Administration and Leadership
Document Type
Article