Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.
Publication/Presentation Date
2-1-2008
Abstract
The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4+CD25+ regulatory T (T(reg)) cells. Details of the mechanism underlying the induction of Foxp3 expression remain unknown, because studies of the transcriptional regulation of the Foxp3 gene are limited by the small number of T(reg) cells in mononuclear cell populations. Here we have generated a model system for analyzing Foxp3 induction and, by using this system with primary T cells, we have identified an enhancer element in this gene. The transcription factors Smad3 and NFAT are required for activity of this Foxp3 enhancer, and both factors are essential for histone acetylation in the enhancer region and induction of Foxp3. These biochemical properties that define Foxp3 expression explain many of the effects of transforming growth factor-beta on the function of Foxp3+ T(reg) cells.
Volume
9
Issue
2
First Page
194
Last Page
202
ISSN
1529-2916
Published In/Presented At
Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008). Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nature immunology, 9(2), 194–202. https://doi.org/10.1038/ni1549
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18157133
Department(s)
Administration and Leadership
Document Type
Article