The effect of retinoic acid on the activation of the human H19 promoter by a 3' downstream region.
Publication/Presentation Date
8-7-1998
Abstract
The human H19 is paternally imprinted (maternally expressed). It is transcribed by RNA pol II, but has no protein product. Its function is unknown. We showed that the transcription of the human H19 gene is under the simultaneous control of both a 5' upstream (promoter) region and a 3' downstream region in cell lines derived from human choriocarcinomas. Moreover, the activation of the H19 promoter by retinoic acid in cells derived from human testicular germ cell tumors is dependent upon the 3' downstream region. The possibility that the action of retinoic acid on the H19 promoter is an indirect one and involves a member of the AP2 transcription factor family is discussed.
Volume
432
Issue
3
First Page
123
Last Page
127
ISSN
0014-5793
Published In/Presented At
Kopf, E., Bibi, O., Ayesh, S., Tykocinski, M., Vitner, K., Looijenga, L. H., de Groot, N., & Hochberg, A. (1998). The effect of retinoic acid on the activation of the human H19 promoter by a 3' downstream region. FEBS letters, 432(3), 123–127. https://doi.org/10.1016/s0014-5793(98)00841-2
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9720909
Department(s)
Administration and Leadership
Document Type
Article