Reversal of the normal pattern of renal choline metabolism during uremia in rats.
Publication/Presentation Date
1-1-1981
Abstract
Chronic uremia was produced in rats by removal of 85% of renal mass. 3 and 8 weeks later in the remnant kidneys the normal ratio of phosphorylcholine/betaine production from 14C-choline (1:2) was reversed. Phosphorylcholine production rose from 24.0 +/- 1.4 to 45.6 +/- 4.5 pmol/min/mg protein (p less than 0.001), and betaine production fell from 51.0 +/- 1.4 to 23.1 +/- 4.5 pmol/min/mg protein (p less than 0.001). This reversed pattern is also found in fetal and neonatal kidneys and during renal compensatory growth.
Volume
28
Issue
4
First Page
204
Last Page
206
ISSN
1660-8151
Published In/Presented At
Bean, G. H., Knight, D. S., & Lowenstein, L. M. (1981). Reversal of the normal pattern of renal choline metabolism during uremia in rats. Nephron, 28(4), 204–206. https://doi.org/10.1159/000182199
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
7301006
Department(s)
Administration and Leadership
Document Type
Article