Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in Stereotactic Body Radiation Therapy for Locally Recurrent Previously-Irradiated Head and Neck Cancer: Report of the AAPM Working Group.

Authors

• John A Vargo
• Vitali Moiseenko
• Jimm Grimm
• Jimmy Caudell
• David A Clump
• Ellen Yorke
• Jinyu Xue
• Yevgeniy Vinogradskiy
• Eduardo G Moros
• Panayiotis Mavroidis
• Sheena Jain
• Issam El Naqa
• Lawrence B Marks
• Dwight E Heron

Publication/Presentation Date

5-1-2021

Abstract

PURPOSE: Stereotactic body radiation therapy (SBRT) has emerged as a viable reirradiation strategy for locally recurrent previously-irradiated head and neck cancer. Doses in the literature have varied, which challenges clinical application of SBRT as well as clinical trial design.

MATERIAL & METHODS: A working group was formed through the American Association of Physicists in Medicine to study tumor control probabilities for SBRT in head and neck cancer. We herein present a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally recurrent previously-irradiated head and neck cancer. Dose-response models are generated that present tumor control probability as a function of dose.

RESULTS: Data from more than 300 cases in 8 publications suggest that there is a dose-response relationship, with superior local control and possibly improved overall survival for doses of 35 to 45 Gy (in 5 fractions) compared with < 30 Gy.

CONCLUSION: Stereotactic body radiation therapy doses equivalent to 5-fraction doses of 40 to 50 Gy are suggested for retreatment.

Volume

110

Issue

1

First Page

137

Last Page

146

ISSN

1879-355X

Published In/Presented At

Vargo, J. A., Moiseenko, V., Grimm, J., Caudell, J., Clump, D. A., Yorke, E., Xue, J., Vinogradskiy, Y., Moros, E. G., Mavroidis, P., Jain, S., El Naqa, I., Marks, L. B., & Heron, D. E. (2021). Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in Stereotactic Body Radiation Therapy for Locally Recurrent Previously-Irradiated Head and Neck Cancer: Report of the AAPM Working Group. International journal of radiation oncology, biology, physics, 110(1), 137–146. https://doi.org/10.1016/j.ijrobp.2018.01.044

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

29477291

Department(s)

Administration and Leadership

Document Type

Article