Shedding of the common acute lymphoblastic leukemia antigen (CALLA) by lymphoblastoid cell lines.

Authors

• Y Komada
• S Peiper
• B Tarnowski
• S Melvin
• H Kamiya
• M Sakurai

Publication/Presentation Date

1-1-1986

Abstract

The release of common acute lymphoblastic leukemia antigen (CALLA) into culture medium by lymphoblastoid cell lines was studied. CALLA release was detected using a solid phase indirect radioimmunometric assay which combines the specificity of lectins and monoclonal antibodies and using immunoadsorption of labeled CALLA in spent medium from cells incubated with 35S-methionine. No CALLA was present in the medium of cells pulse-labeled at 37 degrees C, when they were placed at 4 degrees C, thus this is an active process. Sequential analysis of soluble CALLA revealed shedding of CALLA to be associated with cell growth.

Volume

10

Issue

6

First Page

665

Last Page

670

ISSN

0145-2126

Published In/Presented At

Komada, Y., Peiper, S., Tarnowski, B., Melvin, S., Kamiya, H., & Sakurai, M. (1986). Shedding of the common acute lymphoblastic leukemia antigen (CALLA) by lymphoblastoid cell lines. Leukemia research, 10(6), 665–670. https://doi.org/10.1016/0145-2126(86)90270-5

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

2940422

Department(s)

Administration and Leadership

Document Type

Article