Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
Publication/Presentation Date
11-1-1990
Abstract
The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1;14)(p34;q11) chromosome translocation. By analyzing t(1;14)(p34;q11) chromosomes from a series of patients, we have now identified a discrete region of tal-1 wherein most of the translocation breakpoints occur. Moreover, mapping of tal-1 genomic DNA revealed that coding exons are situated on both sides of the t(1;14)(p34;q11) major breakpoint region. Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential.
Volume
172
Issue
5
First Page
1403
Last Page
1408
ISSN
0022-1007
Published In/Presented At
Chen, Q., Yang, C. Y., Tsan, J. T., Xia, Y., Ragab, A. H., Peiper, S. C., Carroll, A., & Baer, R. (1990). Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. The Journal of experimental medicine, 172(5), 1403–1408. https://doi.org/10.1084/jem.172.5.1403
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2230650
Department(s)
Administration and Leadership
Document Type
Article