Identification of a major co-receptor for primary isolates of HIV-1.
Publication/Presentation Date
6-20-1996
Abstract
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.
Volume
381
Issue
6584
First Page
661
Last Page
666
ISSN
0028-0836
Published In/Presented At
Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., & Landau, N. R. (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature, 381(6584), 661–666. https://doi.org/10.1038/381661a0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8649511
Department(s)
Administration and Leadership
Document Type
Article