Leukocyte transmembrane potential in bipolar illness.
Publication/Presentation Date
11-4-1996
Abstract
Abnormalities in ion regulation and distribution are commonly reported in bipolar disorder. In an effort to determine if these alter cellular physiological function, we determined the transmembrane potential (TMP) in mononuclear leukocytes from normal individuals and patients with bipolar illness either during normal phase or manic and hypomanic episodes. TMP was analyzed by flow cytometry using dihexyloxacarbocyanine iodide (DIOC6(3)), a cationic potential sensitive fluorescent dye. A normal range was established from measurements on leukocytes from 5 control individuals. TMP of manic and hypomanic patients was significantly hyperpolarized (P = 0.0036). The TMP of euthymic bipolar individuals was not different from normal controls. Pathologic moods in bipolar illness may be associated with altered cellular membrane physiology.
Volume
41
Issue
1
First Page
33
Last Page
37
ISSN
0165-0327
Published In/Presented At
El-Mallakh, R. S., Li, R., Worth, C. A., & Peiper, S. C. (1996). Leukocyte transmembrane potential in bipolar illness. Journal of affective disorders, 41(1), 33–37. https://doi.org/10.1016/0165-0327(96)00063-8
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8938203
Department(s)
Administration and Leadership
Document Type
Article