Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.

Authors

• Hirokazu Tamamura
• Ai Esaka
• Teppei Ogawa
• Takanobu Araki
• Satoshi Ueda
• Zixuan Wang
• John O Trent
• Hiroshi Tsutsumi
• Hiroyuki Masuno
• Hideki Nakashima
• Naoki Yamamoto
• Stephen C Peiper
• Akira Otaka
• Nobutaka Fujii

Publication/Presentation Date

12-21-2005

Abstract

Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.

Volume

3

Issue

24

First Page

4392

Last Page

4394

ISSN

1477-0520

Published In/Presented At

Tamamura, H., Esaka, A., Ogawa, T., Araki, T., Ueda, S., Wang, Z., Trent, J. O., Tsutsumi, H., Masuno, H., Nakashima, H., Yamamoto, N., Peiper, S. C., Otaka, A., & Fujii, N. (2005). Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. Organic & biomolecular chemistry, 3(24), 4392–4394. https://doi.org/10.1039/b513145f

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

16327900

Department(s)

Administration and Leadership

Document Type

Article