Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction.
Publication/Presentation Date
12-1-1995
Abstract
STUDY OBJECTIVE: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).
DESIGN: A retrospective, multicenter study.
SETTING: Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years).
PARTICIPANTS: Patients with cocaine-associated MI who received lidocaine in the emergency department.
RESULTS: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).
CONCLUSION: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.
Volume
26
Issue
6
First Page
702
Last Page
706
ISSN
0196-0644
Published In/Presented At
Shih, R. D., Hollander, J. E., Burstein, J. L., Nelson, L. S., Hoffman, R. S., & Quick, A. M. (1995). Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Annals of emergency medicine, 26(6), 702–706. https://doi.org/10.1016/s0196-0644(95)70041-2
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
7492040
Department(s)
Administration and Leadership
Document Type
Article