Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors.
Publication/Presentation Date
4-15-2020
Abstract
BACKGROUND: Nutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, and unintentional weight loss (UWL) in the prior 6 months and chemotherapy toxicity among older adults with solid tumors.
METHODS: This was a secondary analysis of a prospective, multicenter study involving chemotherapy-treated patients 65 years old or older. Geriatric assessment, BMI, albumin level, and UWL data were collected before treatment. Multivariable logistic regression models evaluated the associations between nutritional factors and the risk of grade 3 or higher (grade 3+) chemotherapy toxicity.
RESULTS: Seven hundred fifty patients with a median age of 72 years (range, 65-94 years) and mostly stage IV disease were enrolled. The median pretreatment BMI and albumin values were 26 kg/m
CONCLUSIONS: Among older adults with solid tumors, higher BMIs and normal albumin levels are associated with a lower risk of grade 3+ chemotherapy toxicity. Additional research is warranted to define the clinical significance of nutritional markers and to inform future interventions.
Volume
126
Issue
8
First Page
1708
Last Page
1716
ISSN
1097-0142
Published In/Presented At
Dotan, E., Tew, W. P., Mohile, S. G., Ma, H., Kim, H., Sun, C. L., Caan, B., Dale, W., Gajra, A., Klepin, H. D., Owusu, C., Gross, C. P., Muss, H., Chapman, A., Katheria, V., & Hurria, A. (2020). Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors. Cancer, 126(8), 1708–1716. https://doi.org/10.1002/cncr.32718
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31977084
Department(s)
Administration and Leadership
Document Type
Article