Signaling and regulation of G protein-coupled receptors in airway smooth muscle.
Publication/Presentation Date
1-1-2003
Abstract
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.
Volume
4
Issue
1
First Page
2
Last Page
2
ISSN
1465-993X
Published In/Presented At
Billington, C. K., & Penn, R. B. (2003). Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respiratory research, 4(1), 2.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12648290
Department(s)
Administration and Leadership
Document Type
Article