Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.

Authors

• Pawan Sharma
• Santosh K Yadav
• Sushrut D Shah
• Elham Javed
• John M Lim
• Shi Pan
• Ajay P Nayak
• Reynold A Panettieri
• Raymond B Penn
• Taku Kambayashi
• Deepak A Deshpande

Publication/Presentation Date

12-1-2021

Abstract

Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq-coupled G protein-coupled receptors leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP

Volume

65

Issue

6

First Page

658

Last Page

671

ISSN

1535-4989

Published In/Presented At

Sharma, P., Yadav, S. K., Shah, S. D., Javed, E., Lim, J. M., Pan, S., Nayak, A. P., Panettieri, R. A., Jr, Penn, R. B., Kambayashi, T., & Deshpande, D. A. (2021). Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling. American journal of respiratory cell and molecular biology, 65(6), 658–671. https://doi.org/10.1165/rcmb.2021-0106OC

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

34293268

Department(s)

Administration and Leadership

Document Type

Article