OGR1-dependent regulation of the allergen-induced asthma phenotype.
Publication/Presentation Date
12-1-2021
Abstract
The proton-sensing receptor, ovarian cancer G protein-coupled receptor (OGR1), has been shown to be expressed in airway smooth muscle (ASM) cells and is capable of promoting ASM contraction in response to decreased extracellular pH. OGR1 knockout (OGR1KO) mice are reported to be resistant to the asthma features induced by inhaled allergen. We recently described certain benzodiazepines as OGR1 activators capable of mediating both procontractile and prorelaxant signaling in ASM cells. Here we assess the effect of treatment with the benzodiazepines lorazepam or sulazepam on the asthma phenotype in wild-type (WT) and OGR1KO mice subjected to inhaled house dust mite (HDM;
Volume
321
Issue
6
First Page
1044
Last Page
1044
ISSN
1522-1504
Published In/Presented At
Nayak, A. P., Deshpande, D. A., Shah, S. D., Villalba, D. R., Yi, R., Wang, N., & Penn, R. B. (2021). OGR1-dependent regulation of the allergen-induced asthma phenotype. American journal of physiology. Lung cellular and molecular physiology, 321(6), L1044–L1054. https://doi.org/10.1152/ajplung.00200.2021
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34668419
Department(s)
Administration and Leadership
Document Type
Article