Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma.

Authors

• Miguel Angel Hernandez-Lara
• Santosh K Yadav
• Sushrut D Shah
• Mariko Okumura
• Yuichi Yokoyama
• Raymond B Penn
• Taku Kambayashi
• Deepak A Deshpande

Publication/Presentation Date

10-6-2022

Abstract

Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. However, the molecular signals that regulate ASM growth are not completely understood. Gq-coupled G protein-coupled receptor and receptor tyrosine kinase signaling regulate ASM cell proliferation via activation of phospholipase C, generation of inositol triphosphate (IP

Volume

23

Issue

19

ISSN

1422-0067

Published In/Presented At

Hernandez-Lara, M. A., Yadav, S. K., Shah, S. D., Okumura, M., Yokoyama, Y., Penn, R. B., Kambayashi, T., & Deshpande, D. A. (2022). Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma. International journal of molecular sciences, 23(19), 11868. https://doi.org/10.3390/ijms231911868

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

36233170

Department(s)

Administration and Leadership

Document Type

Article