A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle.

Authors

• Elham Javed
• Ajay P Nayak
• Arun K Jannu
• Aaron H Cohen
• Isabella Dewes
• Ruping Wang
• Dale D Tang
• Deepak A Deshpande
• Raymond B Penn

Publication/Presentation Date

2-1-2025

Abstract

AKAPs (A-kinase-anchoring proteins) act as scaffold proteins that anchor the regulatory subunits of the cAMP-dependent PKA (protein kinase A) to coordinate and compartmentalize signaling elements and signals downstream of Gs-coupled GPCRs (G protein-coupled receptors). The β

Volume

72

Issue

2

First Page

133

Last Page

144

ISSN

1535-4989

Published In/Presented At

Javed, E., Nayak, A. P., Jannu, A. K., Cohen, A. H., Dewes, I., Wang, R., Tang, D. D., Deshpande, D. A., & Penn, R. B. (2025). A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle. American journal of respiratory cell and molecular biology, 72(2), 133–144. https://doi.org/10.1165/rcmb.2023-0358OC

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

39141573

Department(s)

Administration and Leadership

Document Type

Article