Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production.

Authors

• Fred Graumuller
• Diana Cervantes
• Tung O Chan
• Niccolette Schaunaman
• Dominic R Villalba
• Burton F Dickey
• Julia K L Walker
• Hong Wei Chu
• Raymond B Penn

Publication/Presentation Date

5-1-2026

Abstract

BACKGROUND: Numerous in vivo studies have demonstrated beta-2-adrenoceptor (β

METHODS: To explore the potential contribution of airway epithelia in this phenomenon, we compared the ability of ractopamine (RP), recently identified as a Gs-biased beta-agonist, to that of the unbiased/balanced beta-agonist albuterol (ALB), on IL-13-stimulated mucin and cytokine production in human airway epithelia cultures in air-liquid interface (HAE).

RESULTS: ALB, which activates both the β

CONCLUSIONS: These data implicate arrestin-dependent β

Volume

27

Issue

1

ISSN

1465-993X

Published In/Presented At

Graumuller, F., Cervantes, D., Chan, T. O., Schaunaman, N., Villalba, D. R., Dickey, B. F., Walker, J. K. L., Chu, H. W., & Penn, R. B. (2026). Qualitative beta-2-adrenoceptor signaling in the regulation of human airway epithelia mucin and cytokine production. Respiratory research, 27(1), 261. https://doi.org/10.1186/s12931-026-03693-4

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42067931

Department(s)

Administration and Leadership

Document Type

Article