The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR.
Publication/Presentation Date
11-10-2020
Abstract
The recent discovery of sensory (tastant and odorant) G protein-coupled receptors on the smooth muscle of human bronchi suggests unappreciated therapeutic targets in the management of obstructive lung diseases. Here we have characterized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excitation-contraction (E-C) coupling in human ASM cells. Initial studies established multiple odorous molecules capable of increasing intracellular calcium ([Ca
Volume
117
Issue
45
First Page
28485
Last Page
28495
ISSN
1091-6490
Published In/Presented At
Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., Karmacharya, N., Rajkumar, P., Firer, D., Dalesio, N. M., Jude, J., Kurten, R. C., Pluznick, J. L., Deshpande, D. A., Penn, R. B., Liggett, S. B., Panettieri, R. A., Jr, Dong, X., & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences of the United States of America, 117(45), 28485–28495. https://doi.org/10.1073/pnas.2003111117
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33097666
Department(s)
Administration and Leadership
Document Type
Article