Gα
Publication/Presentation Date
12-1-2017
Abstract
BACKGROUND AND PURPOSE: PI3K-dependent activation of Rho kinase (ROCK) is necessary for agonist-induced human airway smooth muscle cell (HASMC) contraction, and inhibition of PI3K promotes bronchodilation of human small airways. The mechanisms driving agonist-mediated PI3K/ROCK axis activation, however, remain unclear. Given that G
EXPERIMENTAL APPROACH: Gα
KEY RESULTS: Knockdown of M
CONCLUSIONS AND IMPLICATIONS: Gα
Volume
174
Issue
23
First Page
4383
Last Page
4395
ISSN
1476-5381
Published In/Presented At
Yoo, E. J., Cao, G., Koziol-White, C. J., Ojiaku, C. A., Sunder, K., Jude, J. A., Michael, J. V., Lam, H., Pushkarsky, I., Damoiseaux, R., Di Carlo, D., Ahn, K., An, S. S., Penn, R. B., & Panettieri, R. A., Jr (2017). Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. British journal of pharmacology, 174(23), 4383–4395. https://doi.org/10.1111/bph.14040
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28921504
Department(s)
Administration and Leadership
Document Type
Article