Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
Publication/Presentation Date
2-1-2018
Abstract
GPCRs have diverse signaling capabilities, based on their ability to assume various conformations. Moreover, it is now appreciated that certain ligands can promote distinct receptor conformations and thereby bias signaling toward a specific pathway to differentially affect cell function. The recently deorphanized G protein-coupled receptor OGR1 [ovarian cancer G protein-coupled receptor 1 ( GPR68)] exhibits diverse signaling events when stimulated by reductions in extracellular pH. We recently demonstrated airway smooth muscle cells transduce multiple signaling events, reflecting a diverse capacity to couple to multiple G proteins. Moreover, we recently discovered that the benzodiazepine lorazepam, more commonly recognized as an agonist of the γ-aminobutyric acid A (GABA
Volume
32
Issue
2
First Page
862
Last Page
874
ISSN
1530-6860
Published In/Presented At
Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Jr, Benovic, J. L., An, S. S., Dulin, N. O., & Penn, R. B. (2018). Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(2), 862–874. https://doi.org/10.1096/fj.201700555R
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
29042451
Department(s)
Administration and Leadership
Document Type
Article