New targets for resolution of airway remodeling in obstructive lung diseases.
Publication/Presentation Date
1-1-2018
Abstract
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR. In this review, we provide a brief overview of the features and putative mechanisms affecting AR. We further discuss recently proposed strategies with promise for deterring or treating AR.
Volume
7
ISSN
2046-1402
Published In/Presented At
Nayak, A. P., Deshpande, D. A., & Penn, R. B. (2018). New targets for resolution of airway remodeling in obstructive lung diseases. F1000Research, 7, F1000 Faculty Rev-680. https://doi.org/10.12688/f1000research.14581.1
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
29904584
Department(s)
Administration and Leadership
Document Type
Article