Agonist-specific desensitization of PGE

Authors

• Francisco J Nunez
• Nancy A Schulte
• David M Fogel
• Joel Michalski
• Stephen I Rennard
• Raymond B Penn
• Myron L Toews
• Rennolds S Ostrom

Publication/Presentation Date

5-1-2020

Abstract

Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3',5'-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E

Volume

393

Issue

5

First Page

843

Last Page

856

ISSN

1432-1912

Published In/Presented At

Nunez, F. J., Schulte, N. A., Fogel, D. M., Michalski, J., Rennard, S. I., Penn, R. B., Toews, M. L., & Ostrom, R. S. (2020). Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts. Naunyn-Schmiedeberg's archives of pharmacology, 393(5), 843–856. https://doi.org/10.1007/s00210-019-01800-5

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31884570

Department(s)

Administration and Leadership

Document Type

Article