Regulation of T cells in airway disease by beta-agonist.
Publication/Presentation Date
6-1-2010
Abstract
It is widely recognized that Th2 cytokines derived from T cells play a major role in the development of allergic lung inflammation that causes most asthma. Beta-agonists are important rescue and maintenance therapies for asthma, yet our understanding of beta-agonist effects on T cell biology is surprisingly poor. Recent studies using both cell culture and more integrative models are beginning to reveal beta-agonist regulation of T cell signaling and function that may be important in the pathogenesis and treatment of asthma and possibly other inflammatory diseases. Here we provide a comprehensive review of the literature concerning beta-agonist effects on T cells, and discuss the relevance of emerging paradigms of beta-adrenergic receptor signaling to T cell function.
Volume
2
Issue
3
First Page
969
Last Page
979
ISSN
1945-0524
Published In/Presented At
Loza, M. J., & Penn, R. B. (2010). Regulation of T cells in airway disease by beta-agonist. Frontiers in bioscience (Scholar edition), 2(3), 969–979. https://doi.org/10.2741/s113
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20515836
Department(s)
Administration and Leadership
Document Type
Article