Regulation of heterotrimeric G protein signaling in airway smooth muscle.
Publication/Presentation Date
1-1-2008
Abstract
Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.
Volume
5
Issue
1
First Page
47
Last Page
57
ISSN
1546-3222
Published In/Presented At
Penn, R. B., & Benovic, J. L. (2008). Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proceedings of the American Thoracic Society, 5(1), 47–57. https://doi.org/10.1513/pats.200705-054VS
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18094084
Department(s)
Administration and Leadership
Document Type
Article