Hemorrhagic complications of enoxaparin and aspirin in patients with kidney transplants.
Publication/Presentation Date
2-1-2002
Abstract
STUDY OBJECTIVE: To evaluate the frequency of early posttransplant hemorrhagic complications in patients with kidney and kidney-pancreas transplants who received thromboprophylaxis with enoxaparin and aspirin.
DESIGN: Retrospective chart review.
SETTING: University-based tertiary care center.
PATIENTS: Thirteen patients who had received enoxaparin within 10 days of kidney or kidney-pancreas transplantation.
INTERVENTION: Medical records were reviewed, and data from patients who had received low-dose aspirin 81 mg once/day and enoxaparin within 10 days of transplantation were collected.
MEASUREMENTS AND MAIN RESULTS: Major bleeding events were defined as intracranial or retroperitoneal bleeding, or a decrease in hemoglobin of greater than 2 g/dl that was confirmed on repeat evaluation. Nine (69%) of the 13 patients had confirmed major bleeding events and required blood transfusions. Six of the nine patients had elevated serum creatinine levels.
CONCLUSION: The combination of enoxaparin and low-dose aspirin early after kidney or kidney-pancreas transplantation was associated with a high frequency of hemorrhagic events. Further evaluation is needed to determine the safety of enoxaparin in combination with aspirin after transplantation.
Volume
22
Issue
2
First Page
184
Last Page
187
ISSN
0277-0008
Published In/Presented At
Shullo, M. A., Rose, M. L., Vivas, C., Jordan, M. L., Scantlebury, V. P., Jain, A., Corry, R. J., Fung, J. J., McCauley, J., Johnston, J., & Shapiro, R. (2002). Hemorrhagic complications of enoxaparin and aspirin in patients with kidney transplants. Pharmacotherapy, 22(2), 184–187. https://doi.org/10.1592/phco.22.3.184.33541
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11837557
Department(s)
Administration and Leadership
Document Type
Article