The question of FK 506 nephrotoxicity after liver transplantation.

Authors

• J McCauley
• S Takaya
• J Fung
• A Tzakis
• K Abu-Elmagd
• A Jain
• S Todo
• T E Starzl

Publication/Presentation Date

2-1-1991

Abstract

Formal studies have not been published on the nephrotoxicity of FK 506 when the drug was used from the outset. This kind of information was sought in 101 recipients of primary livers, 24 hearts, and 3 double lungs or heart-lung. Perioperative renal dysfunction was commonly seen, which appeared to be related to FK 506 doses and plasma levels, particularly when the drug was given IV. This was reversible. Late renal function has been generally satisfactory in all three cohorts of patients, and the incidence of hypertension has been low. The therapeutic index of FK 506 is a good one, as revealed by these observations in patients whose most notable achievement was a low mortality.

Volume

23

Issue

1 Pt 2

First Page

1444

Last Page

1447

ISSN

0041-1345

Published In/Presented At

McCauley, J., Takaya, S., Fung, J., Tzakis, A., Abu-Elmagd, K., Jain, A., Todo, S., & Starzl, T. E. (1991). The question of FK 506 nephrotoxicity after liver transplantation. Transplantation proceedings, 23(1 Pt 2), 1444–1447.

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

1703344

Department(s)

Administration and Leadership

Document Type

Article