Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies.
Publication/Presentation Date
1-1-1994
Abstract
Thirty-eight sequentially placed liver and kidney allografts were evaluated with respect to patient and graft survival, and the influence of preformed lymphocytotoxic antibodies was analysed. The results suggest that the survival rate of combined liver and kidney transplantation is similar to the survival rate of liver transplantation alone. Sequentially placed kidney allografts may be protected from hyperacute rejection in the presence of donor specific lymphocytotoxic antibodies, but not in all instances. Both patient and kidney allograft survival was lower in positive crossmatch patients (33% and 17% respectively) than in negative crossmatch patients (78% and 75%). High levels of panel reactive antibodies (> 10%) also appeared to have a deleterious effect on survival, although the majority of the patients who failed also had a positive crossmatch. Although performed lymphocytotoxic antibodies are not an absolute contraindication to combined liver-kidney transplantation, they do appear to have a deleterious effect on long-term graft survival. However, more correlation with clinical parameters is needed.
Volume
2
Issue
1
First Page
61
Last Page
67
ISSN
0966-3274
Published In/Presented At
Saidman, S. L., Duquesnoy, R. J., Demetris, A. J., McCauley, J., Ramos, H., Mazariegos, G., Shapiro, R., Starzl, T. E., & Fung, J. J. (1994). Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies. Transplant immunology, 2(1), 61–67. https://doi.org/10.1016/0966-3274(94)90080-9
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8081794
Department(s)
Administration and Leadership
Document Type
Article