Outcome of kidney transplantation under tacrolimus-based immunosuppression in elderly patients.

Authors

• A Soran
• R Shapiro
• H Basar
• C Vivas
• V P Scantlebury
• M L Jordan
• H A Gritsch
• J McCauley
• P Randhawa
• T R Hakala
• J J Fung

Publication/Presentation Date

6-1-1999

Abstract

Kidney transplantation has become a reasonable treatment option for selected patients aged 60 years or older, and a number of different immunosuppressive drug protocols have been described. This article concerns 230 recipients who were aged 60 years or older and who were undergoing kidney-only transplantation at the University of Pittsburgh between January 1990 and April 1997. All recipients were treated with a tacrolimus-based immunosuppression regimen. The median follow-up was 31.5 months (range, 1-86). The 1-, 3-, and 5-year actuarial patient survival rates were 90%, 83%, and 76%, respectively. There were 42 (19%) deaths, cardiovascular disease (50%) and infection (38%) being the main causes. Death with a functioning kidney occurred in 28 (67%) patients. The 1-, 3-, and 5-year actuarial graft survival rates were 84%, 74%, and 64%, respectively. The delayed graft function rate was 33%. Rejection was seen in 57 (25%) elderly patients. The mean serum creatinine was 2.6 +/- 2.7 mg/dL and the serum urea nitrogen was 35 +/- 22 mg/dL. The mean tacrolimus level was 8.5 +/- 3.8 ng/mL. These results suggest that renal transplantation in older recipients under tacrolimus-based immunosuppression is associated with reasonable outcomes, and can be offered to appropriately selected patients.

Volume

9

Issue

2

First Page

101

Last Page

103

ISSN

0905-9199

Published In/Presented At

Soran, A., Shapiro, R., Basar, H., Vivas, C., Scantlebury, V. P., Jordan, M. L., Gritsch, H. A., McCauley, J., Randhawa, P., Hakala, T. R., & Fung, J. J. (1999). Outcome of kidney transplantation under tacrolimus-based immunosuppression in elderly patients. Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization (NATCO), 9(2), 101–103. https://doi.org/10.7182/prtr.1.9.2.2034366167382573

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

10703390

Department(s)

Administration and Leadership

Document Type

Article