Ifosfamide chemotherapy and nonconvulsive status epilepticus: case report and review of the literature.
Publication/Presentation Date
7-1-2014
Abstract
We present a patient with peritoneal carcinosarcoma who was treated with the alkylating agent ifosfamide and experienced a rapid decline in mental status. Electroencephalogram (EEG) displayed generalized periodic epileptiform discharges, which raised suspicion for nonconvulsive status epilepticus (NCSE). Following administration of midazolam, the patient's clinical condition and EEG improved. We review the 8 documented cases of ifosfamide-induced NCSE, and demonstrate the similarity in clinical features when compared with ifosfamide neurotoxicity that is not classified as NCSE. EEG findings suggesting an ictal pattern are subtle and heterogeneous, but they are essential for a diagnosis. Since it is unlikely that EEGs are uniformly obtained in instances of ifosfamide neurotoxicity, many cases of NCSE may go unrecognized.
Volume
45
Issue
3
First Page
222
Last Page
225
ISSN
1550-0594
Published In/Presented At
Taupin, D., Racela, R., & Friedman, D. (2014). Ifosfamide chemotherapy and nonconvulsive status epilepticus: case report and review of the literature. Clinical EEG and neuroscience, 45(3), 222–225. https://doi.org/10.1177/1550059413500777
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
24151171
Department(s)
Administration and Leadership
Document Type
Article