Bone marrow-derived cells as progenitors of lung alveolar epithelium.
Publication/Presentation Date
12-1-2001
Abstract
We assessed the capacity of plastic-adherent cultured bone marrow cells to serve as precursors of differentiated parenchymal cells of the lung. By intravenously delivering lacZ-labeled cells into wild-type recipient mice after bleomycin-induced lung injury, we detected marrow-derived cells engrafted in recipient lung parenchyma as cells with the morphological and molecular phenotype of type I pneumocytes of the alveolar epithelium. At no time after marrow cell injection, did we detect any engraftment as type II pneumocytes. In addition, we found that cultured and fresh aspirates of bone marrow cells can express the type I pneumocyte markers, T1alpha and aquaporin-5. These observations challenge the current belief that adult alveolar type I epithelial cells invariably arise from local precursor cells and raise the possibility of using injected marrow-derived cells for therapy of lung diseases characterized by extensive alveolar damage.
Volume
128
Issue
24
First Page
5181
Last Page
5188
ISSN
0950-1991
Published In/Presented At
Kotton, D. N., Ma, B. Y., Cardoso, W. V., Sanderson, E. A., Summer, R. S., Williams, M. C., & Fine, A. (2001). Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development (Cambridge, England), 128(24), 5181–5188. https://doi.org/10.1242/dev.128.24.5181
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11748153
Department(s)
Administration and Leadership
Document Type
Article