Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice.

Authors

• R Summer
• F F Little
• N Ouchi
• Y Takemura
• T Aprahamian
• D Dwyer
• K Fitzsimmons
• B Suki
• H Parameswaran
• A Fine
• K Walsh

Publication/Presentation Date

6-1-2008

Abstract

Adiponectin is an adipocyte-derived collectin that acts on a wide range of tissues including liver, brain, heart, and vascular endothelium. To date, little is known about the actions of adiponectin in the lung. Herein, we demonstrate that adiponectin is present in lung lining fluid and that adiponectin deficiency leads to increases in proinflammatory mediators and an emphysema-like phenotype in the mouse lung. Alveolar macrophages from adiponectin-deficient mice spontaneously display increased production of tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase (MMP-12) activity. Consistent with these observations, we found that pretreatment of alveolar macrophages with adiponectin leads to TNF-alpha and MMP-12 suppression. Together, our findings show that adiponectin leads to macrophage suppression in the lung and suggest that adiponectin-deficient states may contribute to the pathogenesis of inflammatory lung conditions such as emphysema.

Volume

294

Issue

6

First Page

1035

Last Page

1042

ISSN

1040-0605

Published In/Presented At

Summer, R., Little, F. F., Ouchi, N., Takemura, Y., Aprahamian, T., Dwyer, D., Fitzsimmons, K., Suki, B., Parameswaran, H., Fine, A., & Walsh, K. (2008). Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. American journal of physiology. Lung cellular and molecular physiology, 294(6), L1035–L1042. https://doi.org/10.1152/ajplung.00397.2007

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

18326826

Department(s)

Administration and Leadership

Document Type

Article