Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease.
Publication/Presentation Date
9-1-2009
Abstract
Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum and has anti-inflammatory and systemic vascular-protective properties. In this study, we investigated the role of APN in pulmonary vascular homeostasis. We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block TNF-alpha-induced E-selectin upregulation in pulmonary artery endothelial cells. Targeted deletion of the APN gene in mice leads to a vascular phenotype in lung characterized by E-selectin upregulation and age-dependent increases in perivascular inflammatory cell infiltration and pulmonary arterial pressures. Taken together, these findings demonstrate an important role for APN in lung vascular homeostasis and suggest that APN-deficient states may contribute to the pathogenesis of inflammatory pulmonary vascular disease and to the development of pulmonary hypertension.
Volume
297
Issue
3
First Page
432
Last Page
438
ISSN
1522-1504
Published In/Presented At
Summer, R., Fiack, C. A., Ikeda, Y., Sato, K., Dwyer, D., Ouchi, N., Fine, A., Farber, H. W., & Walsh, K. (2009). Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. American journal of physiology. Lung cellular and molecular physiology, 297(3), L432–L438. https://doi.org/10.1152/ajplung.90599.2008
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19561137
Department(s)
Administration and Leadership
Document Type
Article