The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase.

Authors

• Jihui Chen
• Jian Zhang
• Noor F Shaik
• Bing Yi
• Xin Wei
• Xiao-Feng Yang
• Ulhas P Naik
• Ross Summer
• Guijun Yan
• Xinyun Xu
• Jianxin Sun

Publication/Presentation Date

12-20-2019

Abstract

Endothelial nitric oxide (NO) synthase (eNOS) plays a critical role in the maintenance of blood vessel homeostasis. Recent findings suggest that cytoskeletal dynamics play an essential role in regulating eNOS expression and activation. Here, we sought to test whether modulation of cytoskeletal dynamics through pharmacological regulation of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation affects eNOS expression and endothelial function

Volume

294

Issue

51

First Page

19565

Last Page

19576

ISSN

1083-351X

Published In/Presented At

Chen, J., Zhang, J., Shaik, N. F., Yi, B., Wei, X., Yang, X. F., Naik, U. P., Summer, R., Yan, G., Xu, X., & Sun, J. (2019). The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase. The Journal of biological chemistry, 294(51), 19565–19576. https://doi.org/10.1074/jbc.RA119.011317

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31719145

Department(s)

Administration and Leadership

Document Type

Article