Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features.
Publication/Presentation Date
6-1-2009
Abstract
PURPOSE: To identify the prevalence of adrenergically mediated ventricular premature depolarizations (VPDs) and characterize their electrocardiographic (ECG) features and specific anatomically determined sites of origin within the ventricles.
METHODS: VPDs occurring during incremental isoproterenol infusion (3 to 20 mug/min) in 108 patients (30 women, mean age 58 +/- 10 years) with normal ventricular function and no previous ventricular tachycardia (VT) were identified. VPDs were grouped to a probable anatomic region of origin based on 12-lead ECG.
RESULTS: The 235 VPD morphologies (median 2 per patient, range 1-13) were observed in 85/108 (79%) patients. The most frequent regions of origin were: peri-mitral annulus 17%, left-Purkinje network 14%, right ventricle (RV) outflow tract 14%, apical RV free wall 11% and peri-tricuspid annulus 10%. Only 39 (17%) VPDs were not easily classified.
CONCLUSION: Adrenergically mediated VPDs are frequent in patients without structural heart disease or VT and tend to originate from a few anatomic sites.
Volume
25
Issue
1
First Page
43
Last Page
51
ISSN
1572-8595
Published In/Presented At
Rivas, N., Dhruvakumar, S., Mainigi, S. K., Smith, T., Gerstenfeld, E. P., & Marchlinski, F. E. (2009). Ventricular premature depolarizations triggered by incremental dose isoproterenol infusion: common electrocardiographic features. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 25(1), 43–51. https://doi.org/10.1007/s10840-008-9333-z
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19148731
Department(s)
Administration and Leadership
Document Type
Article