Association Between P-Wave Duration, Dispersion, and Interatrial Block and Atrial High-Rate Episodes in CIED Patients.

Authors

• Phuuwadith Wattanachayakul
• Adivitch Sripusanapan
• Narathorn Kulthamrongsri
• Vitchapong Prasitsumrit
• Napat Suriyathumrongkul
• Abiodun Idowu
• Jakrin Kewcharoen
• Sumeet Mainigi

Publication/Presentation Date

11-1-2024

Abstract

INTRODUCTION: Atrial high-rate episodes (AHRE) have been linked to increased thromboembolic risk and all-cause mortality in patients with cardiac implantable electronic devices (CIEDs). Various predictors of AHRE development have been identified, emphasizing the need for close monitoring and the potential transition to clinical atrial fibrillation (AF). However, the predictive value of P wave characteristics on AHRE development remains conflicting. This meta-analysis aims to summarize existing data to investigate this association.

METHOD: We examined studies from MEDLINE and EMBASE databases up to May 2024 to investigate the association of baseline P-wave duration (PWD), P-wave dispersion (PWDIS), and interatrial block (IAB) with the risk of developing AHRE. We extracted the mean and standard deviations of PWD and PWDIS to calculate the pooled mean difference (MD). Risk ratios (RR) and 95% confidence intervals (CIs) were used to assess the association between IAB and AHRE risk, using the generic inverse variance method for combination.

RESULTS: The meta-analysis included nine studies. Patients with AHRE had longer PWD and PWDIS compared to those without AHRE, with a pooled MD for PWD of 9.17 ms (95% CI: 4.74-13.60; I

CONCLUSIONS: Our meta-analysis found that patients with AHRE had higher PWD and PWDIS than those without AHRE. Additionally, IAB was associated with a higher risk of developing AHRE. These findings emphasize the importance of close monitoring and risk stratification, particularly for patients with P wave abnormalities.

Volume

47

Issue

11

First Page

1548

Last Page

1555

ISSN

1540-8159

Published In/Presented At

Wattanachayakul, P., Sripusanapan, A., Kulthamrongsri, N., Prasitsumrit, V., Suriyathumrongkul, N., Idowu, A., Kewcharoen, J., & Mainigi, S. (2024). Association Between P-Wave Duration, Dispersion, and Interatrial Block and Atrial High-Rate Episodes in CIED Patients. Pacing and clinical electrophysiology : PACE, 47(11), 1548–1555. https://doi.org/10.1111/pace.15084

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

39368070

Department(s)

Administration and Leadership

Document Type

Article