Cardiovascular Family History Increases Risk for Late-Onset Adverse Cardiovascular Outcomes in Childhood Cancer Survivors: A St. Jude Lifetime Cohort Report.
Publication/Presentation Date
1-1-2021
Abstract
BACKGROUND: Survivors of childhood cancer have an increased risk of therapy-related cardiovascular disease. It is not known whether family history of cardiovascular disease further increases risk of adverse cardiovascular outcomes among survivors.
METHODS: Family history of cardiovascular disease was collected from 1,260 survivors [median age at diagnosis, 8 years (range, 0-23); age at last follow-up, 35 years (range, 18-66)] of childhood cancer in the St. Jude Lifetime Cohort Study. Multivariable risk models evaluated associations with cardiovascular disease (Common Terminology Criteria for Adverse Events grade 2-4 events) and cardiovascular risk factors.
RESULTS: Among survivors exposed to chest-directed radiation and/or anthracycline chemotherapy (
CONCLUSIONS: Family history of cardiovascular disease and cardiovascular risk factors independently increased risk of heart failure and hypertension among survivors of childhood cancer exposed to cardiotoxic therapies.
IMPACT: These data show the importance of cardiovascular family history as a risk factor for cardiovascular disease in survivors of childhood cancer.
Volume
30
Issue
1
First Page
123
Last Page
132
ISSN
1538-7755
Published In/Presented At
Goldberg, J. F., Ness, K. K., Chi, X., Santucci, A. K., Plana, J. C., Joshi, V. M., Luepker, R. V., Durand, J. B., Partin, R. E., Howell, R. M., Wilson, C. L., Towbin, J. A., Jefferies, J. L., Srivastava, D. K., Hudson, M. M., Robison, L. L., & Armstrong, G. T. (2021). Cardiovascular Family History Increases Risk for Late-Onset Adverse Cardiovascular Outcomes in Childhood Cancer Survivors: A St. Jude Lifetime Cohort Report. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(1), 123–132. https://doi.org/10.1158/1055-9965.EPI-20-0809
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33033146
Department(s)
Administration and Leadership
Document Type
Article