Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
Publication/Presentation Date
9-1-2006
Abstract
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron pathology. Moreover, defects in five Mendelian genes lead to motor neuron disease, with two mutations reproducing the ALS phenotype. Analyses of these genetic effects have generated new insights into the diverse molecular pathways involved in ALS pathogenesis. Here, we present an overview of the mechanisms for motor neuron death and of the role of non-neuronal cells in ALS.
Volume
7
Issue
9
First Page
710
Last Page
723
ISSN
1471-003X
Published In/Presented At
Pasinelli, P., & Brown, R. H. (2006). Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nature reviews. Neuroscience, 7(9), 710–723. https://doi.org/10.1038/nrn1971
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
16924260
Department(s)
Administration and Leadership
Document Type
Article