At-Home Versus in-Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial.
Publication/Presentation Date
9-1-2026
Abstract
INTRODUCTION/AIMS: Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in-clinic assessment remains the standard. We tested concordance between at-home and in-clinic VC to determine trial eligibility, track progression, and predict survival in a large ALS trial.
METHODS: At-home and in-clinic VC were assessed at baseline and approximately every 8 weeks for a year in the first four regimens of the HEALEY ALS Platform Trial. At-home assessments were coached via live videoconference and centrally reviewed. VC measurements, expressed as percent of predicted normal (%PN), were compared cross-sectionally, longitudinally, and for predicting survival time. Data from 233 participants with 3-8 paired at-home and in-clinic VC assessments completed < 14 days apart were analyzed.
RESULTS: At-home and in-clinic VC were well correlated (Lin's r
DISCUSSION: At-home and in-clinic VC were well correlated cross-sectionally. At-home VC performed well tracking longitudinal change and predicting survival. The reduced participant burden of assessment and concordance with in-clinic measurement support use of at-home monitoring of VC.
Volume
74
Issue
3
First Page
702
Last Page
708
ISSN
1097-4598
Published In/Presented At
Macklin, E. A., Berry, J. D., Harkey, B. A., Heyd, L., Chase, M., Yu, H., Sherman, A. V., Dagostino, D., Kittle, G., Hall, M., Connolly, M. R., Drake, K., Giacomelli, E., Scirocco, E., Sharma, S., Babu, S., Benatar, M., Simmons, Z., Young, E., Cudkowicz, M. E., … HEALEY ALS Platform Trial Study Group (2026). At-Home Versus in-Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial. Muscle & nerve, 74(3), 702–708. https://doi.org/10.1002/mus.70322
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42366580
Department(s)
Administration and Leadership
Document Type
Article