EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.

Authors

• Mark W Urban
• Brittany A Charsar
• Nicolette M Heinsinger
• Shashirekha S Markandaiah
• Lindsay Sprimont
• Wei Zhou
• Eric V Brown
• Nathan T Henderson
• Samantha J Thomas
• Biswarup Ghosh
• Rachel E Cain
• Davide Trotti
• Piera Pasinelli
• Megan C Wright
• Matthew B Dalva
• Angelo C Lepore

Publication/Presentation Date

1-15-2024

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contribution to ALS remain incompletely understood. Astrocyte involvement suggests that transcellular signaling may play a role in disease. We examined contribution of transmembrane signaling molecule ephrinB2 to ALS pathogenesis, in particular its role in driving motor neuron damage by spinal cord astrocytes. In symptomatic SOD1

Volume

12

ISSN

2050-084X

Published In/Presented At

Urban, M. W., Charsar, B. A., Heinsinger, N. M., Markandaiah, S. S., Sprimont, L., Zhou, W., Brown, E. V., Henderson, N. T., Thomas, S. J., Ghosh, B., Cain, R. E., Trotti, D., Pasinelli, P., Wright, M. C., Dalva, M. B., & Lepore, A. C. (2024). EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. eLife, 12, RP89298. https://doi.org/10.7554/eLife.89298

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38224498

Department(s)

Administration and Leadership

Document Type

Article