Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Authors

• Andrew T Nelson
• Maria Elena Cicardi
• Shashirekha S Markandaiah
• John Ys Han
• Nancy J Philp
• Emily Welebob
• Aaron R Haeusler
• Piera Pasinelli
• Giovanni Manfredi
• Hibiki Kawamata
• Davide Trotti

Publication/Presentation Date

5-1-2024

Abstract

The most prevalent genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia is a (GGGGCC)

Volume

25

Issue

5

First Page

2479

Last Page

2510

ISSN

1469-3178

Published In/Presented At

Nelson, A. T., Cicardi, M. E., Markandaiah, S. S., Han, J. Y., Philp, N. J., Welebob, E., Haeusler, A. R., Pasinelli, P., Manfredi, G., Kawamata, H., & Trotti, D. (2024). Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes. EMBO reports, 25(5), 2479–2510. https://doi.org/10.1038/s44319-024-00140-7

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38684907

Department(s)

Administration and Leadership

Document Type

Article