Intraclass Correlation in Paired Associative Stimulation and Metaplasticity.
Publication/Presentation Date
12-1-2022
Abstract
Paired associative stimulation (PAS) is a widely used noninvasive brain stimulation protocol to assess neural plasticity. Its reproducibility, however, has been rarely tested and with mixed results. With two consecutive studies, we aimed to provide further tests and a more systematic assessment of PAS reproducibility. We measured intraclass correlation coefficients (ICCs)-a widely used tool to assess whether groups of measurements resemble each other-in two PAS studies on healthy volunteers. The first study included five PAS sessions recording 10 MEPS every 10 min for an hour post-PAS. The second study included two PAS sessions recording 50 MEPS at 20 and 50 min post-PAS, based on analyses from the first study. In both studies PAS sessions were spaced one week apart. Within sessions ICC was fair to excellent for both studies, yet between sessions ICC was poor for both studies. We suggest that long term meta-plasticity effects (longer than one week) may interfere with between sessions reproducibility.
Volume
3
Issue
4
First Page
589
Last Page
603
ISSN
2673-4087
Published In/Presented At
Schapira, G., Chang, J., Kim, Y., Ngo, J. P., Deblieck, C., Bianco, V., Edwards, D. J., Dobkin, B. H., Wu, A. D., & Iacoboni, M. (2022). Intraclass Correlation in Paired Associative Stimulation and Metaplasticity. NeuroSci, 3(4), 589–603. https://doi.org/10.3390/neurosci3040042
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
39483766
Department(s)
Administration and Leadership
Document Type
Article