Supraspinal inputs reduce corticomotor excitability during passive movement: evidence from a pure sensory stroke.
Publication/Presentation Date
1-1-2007
Abstract
Corticomotor excitability is reduced during rhythmic passive movement compared to rest, but it is not known whether the mechanism is purely segmental or includes a supraspinal pathway. To determine how interruption of sensory projections at a supraspinal level affects corticomotor excitability during passive movement, we measured the amplitude of motor evoked potential (MEP) during 1 Hz cyclic index finger movements in a patient with a brainstem and thalamus lesion that resulted in a pure sensory stroke. Measurements of MEP amplitude and proprioception were made 14 and 64 days post-stroke. In the first study, when subjective position sense was reduced for the index finger, MEP amplitude was significantly increased during passive movement compared to rest (4.6+/-0.2 SEM mV vs. 4.0+/-0.2 mV; p=0.0281). However in the second study, when position sense had returned to normal, MEP amplitude was significantly reduced during movement compared to rest (6.2+/-0.3 mV vs. 6.6+/-0.1 mV; p=0.0224). These observations provide evidence that supraspinal sensory pathways are involved in reducing corticomotor excitability during rhythmic passive movement.
Volume
25
Issue
5-6
First Page
527
Last Page
533
ISSN
0922-6028
Published In/Presented At
Edwards, D. J., Mastaglia, F. L., Byrnes, M. L., Fregni, F., Pascual-Leone, A., & Thickbroom, G. W. (2007). Supraspinal inputs reduce corticomotor excitability during passive movement: evidence from a pure sensory stroke. Restorative neurology and neuroscience, 25(5-6), 527–533.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18334770
Department(s)
Administration and Leadership
Document Type
Article