Acute exacerbations of idiopathic pulmonary fibrosis.
Publication/Presentation Date
10-1-2007
Abstract
The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a steady, predictable decline in lung function over time. Recent evidence suggests that some patients may experience a more precipitous course, with periods of relative stability followed by acute deteriorations in respiratory status. Many of these acute deteriorations are of unknown etiology and have been termed acute exacerbations of IPF. This perspective is the result of an international effort to summarize the current state of knowledge regarding acute exacerbations of IPF. Acute exacerbations of IPF are defined as acute, clinically significant deteriorations of unidentifiable cause in patients with underlying IPF. Proposed diagnostic criteria include subjective worsening over 30 days or less, new bilateral radiographic opacities, and the absence of infection or another identifiable etiology. The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed.
Volume
176
Issue
7
First Page
636
Last Page
643
ISSN
1073-449X
Published In/Presented At
Collard, H. R., Moore, B. B., Flaherty, K. R., Brown, K. K., Kaner, R. J., King, T. E., Jr, Lasky, J. A., Loyd, J. E., Noth, I., Olman, M. A., Raghu, G., Roman, J., Ryu, J. H., Zisman, D. A., Hunninghake, G. W., Colby, T. V., Egan, J. J., Hansell, D. M., Johkoh, T., Kaminski, N., … Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators (2007). Acute exacerbations of idiopathic pulmonary fibrosis. American journal of respiratory and critical care medicine, 176(7), 636–643. https://doi.org/10.1164/rccm.200703-463PP
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17585107
Department(s)
Administration and Leadership
Document Type
Article